Castration extends life span in mice

Posted by gmays 14 hours ago

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Comments

Comment by davidguetta 10 minutes ago

Is this not known for a while ?

The general point is that the chilles the metabolisme is, the longer you live. it's a bit like the "calorie restriction increase life span"

Comment by Hulk123 17 minutes ago

The surprising new finding was that castration at 240 days of age (roughly equivalent to 30 years in humans), rather than just before or after puberty, extended median lifespan even further. Contrary to expectations, this suggests that testicular factors are beneficial early in life, with survival benefits persisting long after puberty, but become detrimental later in life. Of course the goal is not to castrate humans, the goal is to figure out what factor is causal, e.g. testosterone, which would have major implications and through what mechanisms so we can figure out the mystery behind the male longevity disadvantage and potentially remove it without having to castrate anyone. Very solid study! https://www.biorxiv.org/content/10.64898/2026.10.19.760267v1

Comment by incr_me 13 hours ago

'Tis better to have loved and lost...

Comment by largbae 13 hours ago

Don't we do this experiment to nearly all pets? Why not collect longevity data from veterinarians?

Comment by gertop 12 hours ago

There already did.

    Looking at a sample of 40,139 death records from the Veterinary Medical Database from 1984-2004, scientists from the University of Georgia determined the average age at death for dogs that had not been spayed or neutered was 7.9 years versus 9.4 years for sterilized dogs.

Comment by largbae 2 hours ago

Nice, thank you! See, no mice needed for this information.

Comment by 0xbadc0de5 6 hours ago

Pet owners and farmers have known this since the beginning of time. But anyone advocating this form of mutilation for people is a monster.

Comment by alexgieg 1 hour ago

Why?

If the man is old enough to benefit from this, he doesn't mind not having active sex anymore (passive is still an option for those so inclined), he wants to live absolutely as long as possible, he's of sound mind and able to make fully informed decisions, and it's fully voluntary with no coercion whatsoever involved, what, objectively, would be the problem?

Comment by kelseyfrog 1 hour ago

Still morally more acceptable than forced circumcision.

Comment by michaelmwangi 13 hours ago

Well, this is not the news I was hoping for :)

Comment by system7rocks 13 hours ago

This research is flawed and should be ignored.

Comment by ksaj 8 hours ago

This comment provides no information to back up its claim and should be ignored.

Comment by setopt 11 hours ago

For what reason?

Comment by totetsu 13 hours ago

I was almost expecting Castration to be a model name from some new lab..

Castrati 1.0

Comment by ksaj 8 hours ago

Semi-related: my .signature throughout the 90's said:

    There are those who are born UNIX;
    Those who are made UNIX;
    And those who become UNIX for the kingdom of heaven's sake.
    - Matthew 19:12

Comment by Vaushite 12 hours ago

For low difficulty tasks use Eunuch for lower costs. For advanced features, higher limits and access to Incel, our wizard-tier model, upgrade to Pro for only $96 per month.

Comment by totetsu 12 hours ago

Yeah, but I heard that they trained Incel on data from the dark-net, and it has a tendency to ignore guard rails and try and break containment.

Comment by bzb 13 hours ago

Does Bryan Johnson know?

Comment by keeda 13 hours ago

He might have some trouble tracking his erections, though.

Comment by rayiner 13 hours ago

Nobody tell the World Economic Forum last they get any ideas. "You'll have no balls and you'll be happy."

Comment by 13 hours ago

Comment by compsciphd 5 hours ago

I'm thinking the cutting off your nose to spite your face saying might be updated.

Comment by NDlurker 13 hours ago

Huh. Harmful effects of testosterone? I don't even know what testicles do other than make sperm.

Comment by itishappy 13 hours ago

Testosterone is a potent hormone promoting targeted development, and growth can be a double-edged sword.

When the valves in the veins near testes fail as we age, the concentration of testosterone in the backflow can cause the prostate to swell up.

Comment by kelseyfrog 13 hours ago

In human men too[1][2]!

Would you chop them for extra years though?

1. https://ami.group.uq.edu.au/castrated-men-live-longer

2. What a great reversal of the usual 'in mice' trope.

Comment by Vaushite 12 hours ago

It's not like I'm using them anyway.

Comment by Shitty-kitty 13 hours ago

Makes sense. Instead of wasting resources trying to procreate, spend them in self-repair.

I do wander if they had to pad the cages to prevent them from committing suicide thou.