Universal vaccine against respiratory infections and allergens
Posted by phony-account 2 hours ago
Comments
Comment by torgoguys 2 hours ago
Comment by MathMonkeyMan 2 hours ago
I wonder if the vaccine causes inflammatory and other unpleasant responses when administered. If so, I wonder if those responses go away after the last dose, when the three months of protection begin.
Here are the two paragraphs that I found interesting:
> The new vaccine, for now known as GLA-3M-052-LS+OVA, mimics the T cell signals that directly stimulate innate immune cells in the lungs. It also contains a harmless antigen, an egg protein called ovalbumin or OVA, which recruits T cells into the lungs to maintain the innate response for weeks to months.
> In the study, mice were given a drop of the vaccine in their noses. Some recieved multiple doses, given a week apart. Each mouse was then exposed to one type of respiratory virus. With three doses of the vaccine, mice were protected against SARS-CoV-2 and other coronaviruses for at least three months.
Comment by Animats 1 hour ago
A new area of research has opened up. This approach may be more useful for treatment than prevention. It's not really a vaccine; it's more like an induced vaccine response. Keeping the immune system in that state full time might be a problem. But after an infection, that's what's wanted.
Comment by rzzzt 2 hours ago
That latter term (ectopic lymphoid structure) comes up in connection with persistent inflammation where the immune system sets up camp near the problem point. Is this good or bad? Do these go away once the infection clears up?
Comment by dillydogg 32 minutes ago
In general, it doesn't surprise me that when you prime the innate immune system, the adaptive immune system works well. The problem is that pathogens have an incredible suite of tools ready to evade these mechanisms. The doses of the pathogens are typically insanely high too, which I do not think model natural infections well. Anyways, this is intriguing, so I'll take a look at the original paper one of these days. Vaccine research generally is so boring. It's like, we vaccinated, and it worked, or didn't, no mechanism.
Comment by ivan_gammel 2 hours ago
Comment by MarkusQ 2 hours ago
We could have paper shredders, blenders, toasters, water taps, and so on that just ran all the time, but our utility bills would be ginormous. Same thing for our bodies.
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Comment by cryzinger 1 hour ago
(That's also why chickenpox can come back later in life as shingles, the same way cold sores recur... because shingles is reactivated chickenpox, it's not a "relabeled" virus...)
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Comment by dennis_jeeves2 1 hour ago
And I intend to copy the Mongoloid one. No royalty for you.
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